FREE ESSAY ON TREATING ANAPHYLAXIS

TREATING ANAPHYLAXIS

TREATING ANAPHYLAXIS
In the emergency setting, anaphylaxis is a dangerous, life threatening condition that
must be treated in an aggressive and timely fashion. Anaphylaxis is a condition related
to acute allergic reactions. Following the body's exposure to the offending allergen,
there are common systemic reactions. The most serious reactions involve the respiratory
and cardiovascular systems, but the gastrointestinal, dermatologic, and genitourinary
systems are often involved causing varied symptoms such as urticaria, flushing,
angioedema, bronchospasm, hypotension, cardiac arrythmias, nausea, intestinal cramps,
pruritus, and finally uterine cramps. (Physician Assistant, 8/94) The above list is by no
means exhaustive, specific symptoms vary from person to person. The same person suffering
from several anaphylactic reactions can also present with differing symptoms. 
Physiologically speaking, the two main effects of the body's released mediators (IgE)
during an anaphylactic reaction are smooth muscle contraction and vasodilatation, which
cause most of the body's adverse symptoms. (JAMA, 11/26/82) Since the most life
threatening reactions usually involve the respiratory and cardiovascular systems, that is
where emergency treatment is focused. In the cardiovascular system, a combination of
vasodilatation, increased vascular permeability, tachcycardia, and arrhythmias can lead
to severe hypotension. In the respiratory system, the swelling of tissues along with
bronchospasm and increased mucus production are the main cause of death. So, if
untreated, anaphylaxis can be fatal as a result of the body's going into what is
essentially shock, while simultaneously (and more importantly) being deprived of the
oxygen needed to sustain life. 
As of today there is one universally accepted treatment for acute anaphylaxis.
Epinephrine. Epinephrine is both an alpha and a beta agonist. This makes it the drug
optimally suited to treat anaphylaxis. Epinephrine will increase vascular resistance,
reduce vascular permeability, produce bronchodilation and increase cardiac output.
(Emergency, 10/93) 
Epinephrine will directly counteract the potentially life threatening aspects of
anaphylaxis. Epinephrine can , and is, used in the both the pre-hospital environment as
well as in definitive care institutions. Epinephrine is widely administered by ALS
providers the world over. The drug is so effective that and relatively simple to use that
...subcutaneous administration of epinephrine by EMT-B's trained in recognition ... of
anaphylaxis... is safe. (Annals of Emergency Medicine, 6/95) 
Following the administration of epinephrine, antihistamines such as diphenhydramine,
hydroxyzine, and promethazine can be administered. These agents block the harmful effects
of histamine, a mediator associated with allergic reactions, and while not displacing
histamine from receptors, they compete with histamine for receptor cites and therefore
block additional histamine from binding. (JEMS, 4/95)
Patients taking beta adrenergic blocking agents will have limited benefits from the
administration of epinephrine (it being a beta agent), as well potentially unopposed
alpha adrenergic effects that could result in severe hypertension. (Physician Assistant,
8/94) In such cases norepinepherine and dopamine may be necessary to treat systemic
anaphylaxis. Glucagon which increases cAMP, is a bronchodilator, and stimulates cardiac
output, can be very useful, even in the presence of beta blockers. (Physician Assistant,
8/94) 
Inhaled bronchodilators are useful for the treatment of respiratory complications
associated with anaphylaxis. There is a wide variety of acceptable agents.
Sympathomimetics such as albuterol, and metaproterenol will relax the smooth muscle in
the respiratory tract. Anticholinergic agents such as ipratropium bromide can also
decrease bronchospasm. Aminophylline, a bronchodilator and diuretic can also increase
intracellular cAMP levels, as well as potentiating catecholamines and stimulating their
release; these effects make it a useful tool in dealing with persistent bronchospasm.
(Physician Assistant, 8/94)
Even though steroids (glucocorticosteroids) have some potentially beneficial effects for
the relief of bronchospasm and hypotension, they are not recommended for the treatment of
acute anaphylactic symptoms due to the fact that it takes four to six hours for them to
be effective. (JAMA, 11/26/82) But, steroids such as methylprednisolone and
hydrocortisone, are useful in shortening the duration of, and reducing the severity of
prolonged anaphylactic reactions, as well as preventing the recurrence of delayed
symptoms. (Physician Assistant, 8/94) 
The above agents are all widely used to treat anaphylaxis. But there are studies and
experiments underway that are looking at alternative, or additional treatments. Naloxone
and thyrotropin-releasing hormone (TRH) are both being looked at in the possible
treatment of anaphylaxis as well as traumatic shock. Naloxone improves cardiovascular
function in a variety of animal models of shock caused by...and anaphylaxis.
Administration of TRH ...also has pressor effects in these shock models. (Annals of
Emergency Medicine, 8/85) 
TRH has been shown to increase mean arterial pressure during anaphylactic shock. (Annals
of Emergency Medicine, 5/89) In animal studies of anaphylaxis the use of TRH,
epinephrine, and normal saline were compared. TRH treated rabbits responded slightly
better than those treated with epinephrine (the study focused on cardiovascular and
respiratory parameters.) (Annals of Emergency Medicine, 5/89)
I started this project with the aim of identifying alternative treatments for
anaphylaxis. I had mistakenly assumed that there are a host of viable and effective
treatment regiments for anaphylactic shock. What I discovered was that as of today, the
only universally accepted therapy for acute anaphylaxis is... epinephrine. Due to it's
alpha and beta adrinergic effects epinephrine is miraculously suited for anaphylaxis. It
almost seems to be a natural antidote, a wonder drug with singular abilities in the
treatment of anaphylaxis.